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PT-141 (Bremelanotide), 10mg
PT-141 (Bremelanotide) is a synthetic cyclic lactam peptide and melanocortin receptor agonist that is a likely metabolite of Melanotan II, differing in that it carries a carboxyl group where MT-II carries an amide.
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Ver resultados de laboratorio →PT-141 (Bremelanotide) is a synthetic cyclic lactam peptide and melanocortin receptor agonist that is a likely metabolite of Melanotan II, differing in that it carries a carboxyl group where MT-II carries an amide. It has high affinity for MC3R and MC4R. Research applications include MC3R/MC4R pharmacology, melanocortin system central/peripheral signalling, and dopaminergic pathway interaction studies.
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3D Molecular Structure
Drag to rotate · scroll to zoomPT-141 (Bremenalotide), 10mg1 vial | KIT (10 vials)
| Chemical Formula | C50H68N14O10 |
|---|---|
| Synonyms | Bremelanotide, PT141, Vyleesi (trade name) |
| Molar Mass | 1,025.2 g/mol |
| CAS Number | 189691-06-3 |
| PubChem CID | 9941379 |
| Total Compound Content | 10 mg per vial |
| Shelf Life | 36 months |
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist developed as a synthetic analogue of Melanotan II. Its primary structural distinction from Melanotan II is the presence of a carboxyl terminus in place of the corresponding amide group, resulting in differences in receptor interaction characteristics and physicochemical properties. PT-141 exhibits high affinity for melanocortin receptor subtypes MC3R and MC4R and has been extensively investigated as a research tool for melanocortin receptor pharmacology and receptor-mediated signaling mechanisms.
Experimental studies have examined the relationship between PT-141 and melanocortin receptor activation, ligand-receptor binding dynamics, receptor subtype selectivity, and downstream signaling pathways associated with MC3R and MC4R activity. Research applications include melanocortin receptor characterization, receptor pharmacology, structure-activity relationship investigations, ligand-receptor interaction studies, and mechanistic evaluation of melanocortin signaling systems. Supplied as a lyophilized preparation (10 mg/vial). Independently third-party HPLC-tested; COA available per batch.
Results refer to the tested sample. Check the batch and date in the report.
What distinguishes PT-141 from other melanocortin receptor agonists?
PT-141 is a cyclic heptapeptide melanocortin receptor agonist characterized by high affinity for MC3R and MC4R receptor subtypes. Its receptor interaction profile differs from other melanocortin ligands through variations in receptor subtype selectivity, binding characteristics, and signaling activity.
These properties have established PT-141 as a valuable research tool for investigating melanocortin receptor pharmacology, receptor-mediated signaling mechanisms, and ligand-receptor interactions.
What is the structural difference between PT-141 and Melanotan II?
PT-141 and Melanotan II share a closely related cyclic heptapeptide framework but differ at the C-terminal region of the molecule. PT-141 contains a free carboxyl group, whereas Melanotan II contains a corresponding amide functionality.
This structural variation influences physicochemical properties, receptor interaction characteristics, and pharmacological behavior, making the two compounds useful for comparative structure-activity relationship investigations within melanocortin receptor research.
Why is PT-141 useful for MC3R and MC4R research?
PT-141 exhibits strong activity at MC3R and MC4R receptor subtypes and has been extensively utilized in studies examining receptor activation, ligand-binding dynamics, receptor subtype selectivity, and downstream melanocortin signaling pathways. Its well-characterized pharmacological profile makes it a useful research tool for investigations involving melanocortin receptor biology, receptor pharmacology, signal transduction mechanisms, and comparative analyses of melanocortin receptor agonists.
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